| 名稱 | CD40/CHO |
| 型號(hào) | CBP74034 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CD40/CHO，凍存條件：90% FBS+10% DMSO |
產(chǎn)品搜索
相關(guān)文章
- 喝熱茶或使食管癌風(fēng)險(xiǎn)增加5倍
- 證據(jù)：鍛煉或許并不是控制體重的關(guān)鍵
- 關(guān)于sigma試劑的使用時(shí)長(zhǎng)相關(guān)說(shuō)明
- 肺癌靶向治療：腫瘤不進(jìn)展時(shí)間超2年
- 一箭雙雕——IL-4R靶點(diǎn)和IL-4/IL-13雙重阻斷藥篩細(xì)胞模型
- IL36靶點(diǎn)藥物細(xì)胞篩選模型藥
- 腫瘤細(xì)胞培養(yǎng)實(shí)驗(yàn)的主要用途
- CCR8 | 潛在重磅腫瘤免疫治療靶點(diǎn)
- TIGIT&PVRIG雙靶點(diǎn)細(xì)胞篩選模型
- 重磅！科學(xué)家成功利用免疫細(xì)胞運(yùn)輸抗癌藥物至腫瘤靶點(diǎn)
聯(lián)系我們
聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74034CD40/CHO
- 詳細(xì)內(nèi)容
| CBP74034 | |
| I. Background | |
| CD40, a TNF receptor superfamily member, was initially identified on B lymphocytes. However, other cell types such as monocytes, basophils, dendritic cells, endothelial cells, and epithelial cells have been found to express CD40. High levels of CD40 have also been detected in numerous human cancers, including HCT116, a colon cancer epithelial cell line. Interaction with CD40 ligand (CD40L, CD154) on CD4+ T helper lymphocytes triggers the expression of intercellular adhesion molecule (ICAM) and other pro-inflammatory cytokines. CD40:CD40L signaling simultaneously increases activation of antigen-specific T cells. CD40 also activates NF-κB-dependent signaling in response to lipopolysaccharide (LPS) found on Gram negative bacterial pathogens. Agonistic CD40 monoclonal antibodies have been shown to activate antigen presenting cells (APC), promote anti-tumor T-cell responses, and to foster cytotoxic myeloid cells, suggesting a potential mechanism to control cancer in the absence of T-cell immunity. | |
| II. Description | |
Recombinant CHO cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5; TNFRSF5), Genbank Accession No. NP_001241.1. | |
| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | CD40 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12k+10%FBS+5ug/ml puromycin |
| Application(s): | Binding Assay,FACS |
| Storage: | Liquid nitrogen |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
 | |
Figure 1. Recombinant CHO cell line expressing full length human CD40. | |
會(huì)員_a.png)